~ Preclinical information present the utility of Gennao’s proprietary first-in-class monoclonal antibody 3E10-D31N (GMABD31N), a cell penetrating antibody, to non-covalently bind to and systemically ship therapeutic ranges of a number of sorts of nucleic acid payloads to cells in vitro and tumors in vivo ~
~ GMABD31N mixed with a RIG-I ligand 3pRNA (GMABD31N/3pRNA) effectively targets and delivers a identified RIG-I agonist to tumors in vivo and successfully prevents tumor progress in a mouse mannequin of melanoma, akin to anti-CTLA-4 ~
NEW HAVEN, Conn., April 10, 2021 (GLOBE NEWSWIRE) — Gennao Bio, a privately-held genetic medicines firm creating first-in-class, focused nucleic acid therapeutics, at present introduced a late-breaking poster detailing preclinical outcomes for its proprietary, non-viral gene monoclonal antibody (GMAB) nucleic acid supply system. The info had been offered on the American Affiliation for Most cancers Analysis (AACR) Annual Assembly 2021.
The GMAB know-how platform, completely licensed from Yale College, makes use of a proprietary, cell-penetrating antibody to non-covalently bind to and ship therapeutic ranges of a number of sorts of nucleic acids, together with artificial RNA (ribonucleic acid) messenger RNA, small interfering RNA, deoxyribonucleic acids, antisense oligonucleotides and gene enhancing molecules.
The preclinical information offered within the poster present the utility of the monoclonal antibody 3E10-D31N (GMABD31N) to ship nucleic acids to cells in vitro and to tumors in vivo. This antibody, a modified model of 3E10, varieties non-covalent complexes with RNAs and might mediate extremely particular supply broadly into tumors through intravenous injection by concentrating on the nucleoside transporter ENT2. ENT2 is extremely expressed in a number of tumor varieties in addition to skeletal and cardiac muscle.
Research accomplished with labeled RNAs and messenger RNAs expressing a inexperienced fluorescent protein reporter gene present tumor particular supply and practical expression by imaging, with minimal supply to wholesome tissues. Cell tradition research present antibody-mediated supply of a sequence of retinoic acid-inducible gene I (RIG-I) ligands, together with hairpin RNAs and artificial double-stranded RNA (poly(I:C)), leading to strong RIG-I stimulation and induction of type-1 interferon signaling. Most significantly, when utilizing a mouse B16 melanoma tumor mannequin, substantial tumor progress suppression was noticed upon intravenous injection of GMABD31N non-covalently sure to 3pRNA, an 89-nucleotide, single-stranded RNA. On this research, the tumor suppression noticed was akin to the tumor suppression that was noticed utilizing anti-CTLA-4.
“The preclinical outcomes offered at present spotlight the power of GMABD31N to systemically ship immunostimulatory RNAs in a focused, non-invasive method,” stated Peter M. Glazer, M.D., Ph.D., Chair of the Division of Therapeutic Radiology, Professor of Genetics and Robert E. Hunter Professor of Therapeutic Radiology on the Yale College of Medication. “This strategy has the potential to supply new and vital remedy benefits over present supply strategies which might be related to systemic toxicity or depend on direct intra-tumoral injection, which is therapeutically sub-optimal, particularly for metastatic illness. I sit up for working with Gennao Bio on the continued growth of the GMAB platform to develop efficient therapeutics for the remedy of oncology indications, in addition to monogenic skeletal and cardiac muscle ailments.”
The complete summary and poster presentation may be accessed on the AACR annual assembly web site, www.aacr.org, via June 21, 2021.
About Gennao Bio
Gennao Bio is a privately-held genetic medicines firm creating first-in-class focused nucleic acid therapeutics using its proprietary gene monoclonal antibody (GMAB) platform know-how. GMAB know-how makes use of a novel, cell-penetrating antibody to non-covalently bind to and ship therapeutic ranges of all kinds of nucleic acid payloads to pick out cells. This non-viral supply platform affords vital benefits over conventional gene supply methods as it might ship a number of sorts of nucleic acids, permits for repeat dosing and dose optimization, and may be simply and affordably manufactured. Gennao Bio is creating this supply system with an preliminary deal with oncology and monogenic skeletal muscle ailments.
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